Dr Audrey Chan

Audrey completed her PhD in 2017 at The University of Western Australia, where she focused on receptor trafficking in bone biology. She then moved to Melbourne and worked briefly at St. Vincent’s Institute for Medical Research before joining the Centre for Muscle Research at The University of Melbourne as a Research Support Officer and Research Fellow. Here, her research focused on understanding the complexities of interorgan bone-muscle crosstalk. She has now moved back to Perth where she is keen to apply her experiences and knowledge of the musculoskeletal system to improve the quality of life in health, disease and ageing.

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Research Scientist
Publications

ORCID 0000-0002-9417-0718

2025

  • Swiderski, K., Trieu, J., Chee, A., Naim, T., Brock, C. J., Baum, D. M., Chan, A. S., Hardee, J. P., Li, W., Kueh, A. J., Herold, M. J., Murphy, K. T., Gregorevic, P., & Lynch, G. S. (2025). Altering phosphorylation of dystrophin S3059 to attenuate cancer cachexia. Life Sciences, 362, 123343. https://doi.org/10.1016/j.lfs.2024.123343

2024

  • Swiderski, K., Chan, A. S., Herold, M. J., Kueh, A. J., Chung, J. D., Hardee, J. P., Trieu, J., Chee, A., Naim, T., Gregorevic, P., & Lynch, G. S. (2024). The BALB/c.mdx62 mouse exhibits a dystrophic muscle pathology and is a model of Duchenne muscular dystrophy. Disease Models & Mechanisms, 17(4), dmm050502. https://doi.org/10.1242/dmm.050502

2023

  • Chan, A. S., Hardee, J. P., Blank, M., Cho, E. H., McGregor, N. E., Sims, N. A., & Lynch, G. S. (2023). Increasing muscle contractility through low-frequency stimulation alters tibial bone geometry and reduces bone strength in mdx and dko dystrophic mice. Journal of Applied Physiology (Bethesda, Md.: 1985), 135(1), 77–87. https://doi.org/10.1152/japplphysiol.00651.2022

2022

  • McGregor, N. E., Walker, E. C., Chan, A. S., Poulton, I. J., Cho, E. H., Windahl, S. H., & Sims, N. A. (2022). STAT3 Hyperactivation Due to SOCS3 Deletion in Murine Osteocytes Accentuates Responses to Exercise- and Load-Induced Bone Formation. Journal of Bone and Mineral Research, 37(3), 547–558. https://doi.org/10.1002/jbmr.4484

2021

  • Hardee, J. P., Caldow, M. K., Chan, A. S. M., Plenderleith, S. K., Trieu, J., Koopman, R., & Lynch, G. S. (2021). Dystrophin deficiency disrupts muscle clock expression and mitochondrial quality control in mdx mice. American journal of physiology. Cell physiology, 321(2), C288–C296. https://doi.org/10.1152/ajpcell.00188.2021
  • Swiderski, K., Read, S. J., Chan, A. S., Chung, J. D., Trieu, J., Naim, T., Koopman, R., & Lynch, G. S. (2021). Investigating the Potential for Sulforaphane to Attenuate Gastrointestinal Dysfunction in mdx Dystrophic Mice. Nutrients, 13(12), 4559. https://doi.org/10.3390/nu13124559
  • Walker, E. C., McGregor, N. E., Chan, A. S. M., & Sims, N. A. (2021). Measuring Bone Volume at Multiple Densities by Micro-computed Tomography. Bio-protocol, 11(1), e3873. https://doi.org/10.21769/BioProtoc.3873
  • Tian, L., Jabbari, J. S., Thijssen, R., Gouil, Q., Amarasinghe, S. L., Voogd, O., Kariyawasam, H., Du, M. R. M., Schuster, J., Wang, C., Su, S., Dong, X., Law, C. W., Lucattini, A., Prawer, Y. D. J., Collar-Fernández, C., Chung, J. D., Naim, T., Chan, A., Ly, C. H., … Ritchie, M. E. (2021). Comprehensive characterization of single-cell full-length isoforms in human and mouse with long-read sequencing. Genome Biology, 22(1), 310. https://doi.org/10.1186/s13059-021-02525-6

2019

  • Ho, P. W. M., Chan, A. S., Pavlos, N. J., Sims, N. A., & Martin, T. J. (2019). Brief exposure to full length parathyroid hormone-related protein (PTHrP) causes persistent generation of cyclic AMP through an endocytosis-dependent mechanism. Biochemical Pharmacology, 169, 113627. https://doi.org/10.1016/j.bcp.2019.113627

2018

  • Johnson, R. W., Sun, Y., Ho, P. W. M., Chan, A. S. M., Johnson, J. A., Pavlos, N. J., Sims, N. A., & Martin, T. J. (2018). Parathyroid Hormone-Related Protein Negatively Regulates Tumor Cell Dormancy Genes in a PTHR1/Cyclic AMP-Independent Manner. Frontiers in Endocrinology, 9, 241. https://doi.org/10.3389/fendo.2018.00241

2016

  • Clairfeuille, T., Mas, C., Chan, A. S., Yang, Z., Tello-Lafoz, M., Chandra, M., Widagdo, J., Kerr, M. C., Paul, B., Mérida, I., Teasdale, R. D., Pavlos, N. J., Anggono, V., & Collins, B. M. (2016). A molecular code for endosomal recycling of phosphorylated cargos by the SNX27-retromer complex. Nature Structural & Molecular Biology, 23(10), 921–932. https://doi.org/10.1038/nsmb.3290
  • Tiulpakov, A., White, C. W., Abhayawardana, R. S., See, H. B., Chan, A. S., Seeber, R. M., Heng, J. I., Dedov, I., Pavlos, N. J., & Pfleger, K. D. (2016). Mutations of Vasopressin Receptor 2 Including Novel L312S Have Differential Effects on Trafficking. Molecular Endocrinology (Baltimore, Md.), 30(8), 889–904. https://doi.org/10.1210/me.2016-1002
  • Chan, A. S., Clairfeuille, T., Landao-Bassonga, E., Kinna, G., Ng, P. Y., Loo, L. S., Cheng, T. S., Zheng, M., Hong, W., Teasdale, R. D., Collins, B. M., & Pavlos, N. J. (2016). Sorting nexin 27 couples PTHR trafficking to retromer for signal regulation in osteoblasts during bone growth. Molecular Biology of the Cell, 27(8), 1367–1382. https://doi.org/10.1091/mbc.E15-12-0851